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Wesley B. Denny, Ph.D.

Staff Scientist

Office:
USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, AL. 36604
(251) 445-9832
(251) 445-9893 lab
wdenny@jaguar1.usouthal.edu

Research Interests:
-Signaling pathways involved in modulating inflammatory, immunosuppressive, and pro-oncogenic responses, especially those mediated by the glucocorticoid receptor and NF-kappaB.
-Protein modeling and investigation of protein-protein interactions, particularly multi-protein complexes.

Honors and Academic Achievements:
-Alpha Eta - Allied Health Professions Honors Society, 2009

Education:
-Ph.D., Basic Medical Sciences, University of South Alabama, Mobile, AL., 2004
-B.S., Medical Technology, University of South Alabama, Mobile, AL., 1996

Professional Memberships:
-American Society for Clinical Pathology, member, 1996-present
-American Chemical Society, member, 1986-present

Dr. Wesley Denny is a staff scientist at the Mitchell Cancer Institute Center for Basic and Translational Science under the direction of Dr. Eddie Reed, Clinical Director. His work focuses on understanding the molecular interaction of BRCT-domain proteins involved in base-excision repair of damaged DNA. By understanding the interaction of these DNA repair proteins, it is hoped that novel therapies targeting DNA repair processes in cancer cells will be developed that enhance the efficacy of anti-cancer treatments.

1. Denny, W.B., Prapapanich, V., Smith, D.F., and Scammell, J.G. (2005). Structure-function analysis of squirrel monkey FKBP51, a potent inhibitor of glucocorticoid receptor activity. Endocrinology 146: 3194-3201.

2. Scammell, J.G., Hubler, T.R., Denny, W.B., and Valentine, D.L. (2003). Organization of the human FK506-binding immunophilin FKBP52 protein gene (FKBP4). Genomics 81: 640-643.

3. Hubler, T.R., Denny, W.B., Valentine, D.L., Cheung-Flynn J., Smith, D.F., and Scammell, J.G. (2003). The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. Endocrinology 144: 2380-2387.

4. Scammell, J.G., Denny, W.B., Valentine, D.L., and Smith, D.F. (2001). Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. General and Comparative Endocrinology 124: 152-165.

5. Denny, W.B., Valentine, D.L., Reynolds, P.D., Smith, D.F., and Scammell, J.G. (2000). Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141: 4107-4113.

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