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Yaguang Xi, M.D., Ph.D.

Assistant Professor of Oncologic Sciences

Office:
USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, AL. 36604
(251) 445-9857 (Phone)
(251) 460-6994 (Fax)
xi@usouthal.edu

Research Interests:
-Discovery and validation of novel biomarkers associated with tumor progression, metastasis, therapeutic response, and chemoprevention.
-Identification and characterization of important roles of non-coding RNA (microRNAs) in human cancer.
-Developing new normalization methods for microarray analysis.

Honors and Academic Achievements:
-American Society of Clinical Oncology, Merit Award, 2008.
-American Association for Cancer Research Aflac Scholar-In-Training Award, 2007 & 2008
-World Health Organization- International Agency for Research on Cancer, Special Training Award, France, 2004.
-Outstanding Academic Researcher Award, Peking University, China, 2003.
-Innovator Award, Peking University, China, 2002.

Education:
-Ph.D., Peking University, China. (2003)
-M.D., Inner Mongolia Medical College, China. (1996)

Professional Appointments:
-Member, USA Mitchell Cancer Institute, 2008 – present

Professional Memberships:
-American Association for Cancer Research, 2004-present
-American Society of Clinical Oncology, 2005-present

Service:
-Editorial Board Member: Thoracic Cancer, ScientificWorldJournal, and Micro RNA
-Invited reviewer: Annals of Oncology, BBA - General Subjects, BMC Boinformatics, BMC Cancer, BMC genomics, Cancer Genetics, Chemotherapy, Clinical and Experimental Hypertension, Clinical Oncology and Cancer Research, International Journal of Biomedical Science, International Journal of Cancer, International Journal of Immunogenetics, Journal of Chemotherapy, Journal of Translational Medicine, Molecular Cancer, Medicinal Research Reviews, and Ochsner Journal
-Grant reviewer: Peer Reviewed Cancer Research Program, DOD (2012), Genesis Oncology Trust, New Zealand (2011)

Dr. Yaguang Xi is an assistant professor of oncologic sciences at the Mitchell Cancer Institute. His laboratory focuses on the discovery and validation of novel biomarkers associated with tumor progression, metastasis, therapeutic response, and prevention using high throughput genomic technologies including microarray, real-time PCR and Luminex xMAP technology. Currently on-going projects are aimed at exploring the important role of microRNA in human colorectal cancer, breast cancer, leukemia, and osteosarcoma.

MicroRNAs are a set of non-coding small RNA molecules. The total number of microRNAs are approximately 1,500 but they are regulating up to 1/3 of human genes at post-transcriptional and/or translational levels. MicroRNA has been recognized as an important regulator to involve many essential biological events including development, cell growth, differentiation, apoptosis, and tumorigenesis. Motivated to translate their accomplishments from the bench into the clinic, Dr. Xi’ team is devoted to explore important functions of microRNA and expects to find a cure for cancer.

Publications in 2011:
1. Li, X., Gao, L., Cui, Q., Gary, B., Dyness, DL., Taylor, W., Shevde-Samant, LR., Samant, RS., Dean-Colomb, W., Piazza, GA., Xi, Y. (2011) Sulindac inhibits tumor cell invasion by suppressing NF-?B mediated transcription of microRNAs. Oncogene. In press.

2. Gao, L., Gao, Y., Li, X., Howell, P., Kumar, R., Su, X., Vlassov, AV., Piazza, GA., Riker, AI., Sun, D., Xi, Y. (2011) Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Mol Oncol. In press.

3. Li, X., Zhang, J., Gao, L., McClellan, S., Finan, M., Butler, TW., Owen, LB., Piazza, GA., Xi, Y. (2011) MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death Differ. In press.

4. Li, X., Wainscott, C., Xi, Y. (2011) MicroRNA provides insight for understanding esophageal cancer. Thoracic Cancer. 2(4): 134-142.

5. Wang, B., Wang, XF., Xi, Y. (2011) Normalizing bead-based microRNA expression data: a measurement error model-based approach. Bioinformatics. 27(11):1506-1512

6. Risberg, K., Guldvik, IJ., Palchaudhuri, R., Xi, Y., Ju, J., Fodstad, O., Hergenrother, PJ., Andersson, Y. (2011) Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins. J Immunother. 34(5):438-447.

7. Kumar, R., Xi, Y. (2011) MicroRNAs, epigenetic machinery, and lung cancer. Thoracic Cancer. 2(2): 35-44

8. Wang, B., Howell, P., Bruheim, S., Ju, J., Owen, L., Fodstad,O., Xi, Y. (2011) Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLoS ONE. 6(2):e17167.

9. Li, X. and Xi, Y. (2011). Predictive Capacity and Functional Significance of MicroRNA in Human Melanoma, Research on Melanoma - A Glimpse into Current Directions and Future Trends, Mandi Murph (Ed.), ISBN: 978-953-307-293-7, InTech. (Book Chapter)

Other Selected Publications:
1. Kudo, K., Xi, Y., Wang, Y., Song, B., Chu, E., Ju, J., Russo, JJ., Ju, J. (2010) Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip). Nucleic Acids Res. 38(9):e104

2. Howell, P., Li, X., Riker, AI., Xi, Y. (2010) MicroRNA in Melanoma. Ochsner J. 10(2):83-92.

3. Wang, B., Wang, XF., Howell, P., Qian, X., Huang, K., Riker, Al., Ju, J., Xi, Y. (2010) A personalized microRNA microarray normalization method using a logistic regression model. Bioinformatics 26(2): 228-234.

4. Bruheim, S., Xi, Y., Ju, J., Fodstad, O. (2009) Gene expression profiles classify human osteosarcoma xenografts according to sensitivity to doxorubicin, cisplatin, and ifosfamide. Clin Cancer Res. 15(23):7161-7169

5. Xi, Y., Nakajima, G., Gavin, E., Morris, C., Kudo, K., Kazuhiko Hayashi, K., Ju, J. (2007) Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA 13(10): 1668-1674.

6. Xi, Y., Nakajima, G., Hamil, T., Fodstad, O., Riker, A., Ju, J. (2006) IGFBP-3 expression is associated with tumor progression in melanoma. Mol Cancer Ther. 5(12): 1-7.

7. Xi, Y., Nakajima, G., Schmitz, J.C., Chu, E., Ju, J. (2006) Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics 7(1): 68.

8. Xi, Y., Shalgi, R., Fodstad, O., Pilpel, Y., Ju, J. (2006) Differentially Regulated miRNAs and actively translated mRNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res. 12 (7): 2014-2024.

9. Xi, Y., Ding,K., Su,X., Chen,D., You,W., Shen, Y., Ke,Y. (2004) p53 polymorphism and p21WAF1/CIP1 haplotype in the intestinal gastric cancer and the precancerous lesions. Carcinogenesis 25(11): 2201-2206

10. Xi, Y., Ding, K., Ren, Y., Shen, Y., Ke, Y. (2002) Esophageal cancer in Chinese population: no polymorphism in codon 149 of P21Waf1/Cip1 cyclin dependent kinase gene. Oncogene 21 (50): 7745-7748.

-AACR-Colorectal Cancer Coalition Fellows Grant, in memory of Lisa Dubow
Role: Xi (PI)
Period: July 1, 2008-December 31, 2009
Grantors: American Association for Cancer Research & Colorectal Cancer Coalition (C3)
Title: MicroRNAs, novel biomarkers in colorectal cancer

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