Intracellular Survival of Burkholderia pseudomallei and Burkholderia mallei
Dr. Mary N. Burtnick, assistant professor, received her Ph.D. in Bacterial Pathogenesis from the University of Calgary, Calgary, Alberta in 2002. Dr. Burtnick carried out her postdoctoral studies at the Genomics Institute of the Novartis Research Foundation in San Diego, California and at Rocky Mountain Laboratories, NIAID, NIH in Hamilton, Montana. Dr. Burtnick joined the University of South Alabama College of Medicine Microbiology and Immunology faculty in November 2008. Dr. Burtnick serves as an ad hoc reviewer for Protein Expression & Purification and Microbiology.
Research in our lab is focused on identifying the molecular mechanisms used by Burkholderia pseudomallei and Burkholderia mallei to persist within eukaryotic cells. Specifically, we are interested in determining how the type VI secretion systems (T6SS) expressed by these pathogens facilitate survival and replication within a variety of human and murine cell types.
Recent Publications
Brett PJ, Burtnick MN, Fenno JC, Gherardini FC. Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor. Mol Microbiol. 2008 Oct;70(2):396-409. Epub 2008 Aug 27.
Burtnick MN, Brett PJ, Nair V, Warawa JM, Woods DE, Gherardini FC. Burkholderia pseudomallei type III secretion system mutants exhibit delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages. Infect Immun. 2008 Jul;76(7):2991-3000. Epub 2008 Apr 28.
Brett PJ, Burtnick MN, Su H, Nair V, Gherardini FC. iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages. Cell Microbiol. 2008 Feb;10(2):487-98. Epub 2007 Oct 28.
Burtnick MN, Downey JS, Brett PJ, Boylan JA, Frye JG, Hoover TR, Gherardini FC. Insights into the complex regulation of rpoS in Borrelia burgdorferi. Mol Microbiol. 2007 Jul;65(2):277-93. Epub 2007 Jun 21.
Brett PJ, Burtnick MN, Snyder DS, Shannon JG, Azadi P, Gherardini FC. Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes. Mol Microbiol. 2007 Jan;63(2):379-90. Epub 2006 Dec 5.
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