15th International Symposium on Trace Elements in Man and Animals
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Collins, James F., Ph.D.

Associa collins 175x202 te Professor

Contact Information

572 Newell Dr.
FSHN Building
Room 441A
P.O. Box 110370
Gainesville, FL 32611-0370

Phone: 352.392.1991 ext. 289
Email: jfcollins@ufl.edu
Website: http://fshn.ifas.ufl.edu/james-f-collins/

Education

  • Post Doc. University of Arizona; Transport Physiology, 1997
  • Ph.D. Vanderbilt University; Molecular Physiology, 1994
  • M.S. Middle Tennessee State University; Molecular Biology, 1991
  • B.S. University of the South (Sewanee); Biology, 1987

Research Interests

Dr. Collins’ research interests include molecular mechanisms of intestinal iron transport, the influence of copper on iron homeostasis, nutrient-gene interactions (i.e. nutrigenomics), nutrient control of gene transcription, and iron absorption during inflammatory states (e.g. anemia of chronic disease).

Classes Taught

Undergraduate

HUN 2201 – Fundamentals of Human Nutrition (Fall/Spring)

Graduate

HUN 6356- Minerals In Nutrition (Iron & copper lectures)

Recent Publications

Xie, L., Collins, J.F. (2013) Transcription Factors Sp1 and Hif2a Mediate Induction of the Copper-Transporting ATPase (Atp7a) Gene in Intestinal Epithel;ial Cells During Hypoxia. J. Biol. Chem. doi:10.1074/jbc.M113.489500. Published online June 28, 2013.

Gulec, S., Collins, J.F. (2013) Investigation of Iron Metabolism in Mice Expressing a Mutant Menke’s Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; MoBr/y). PLOS ONE, 11;8(6):e66010. doi: 10.1371/journal.pone.0066010.

Xie, L., Collins, J.F. (2012) Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein in rat intestinal epithelial cells. Am. J. Physiol. Cell Physiol., 304(3):C257-62

Lu, Y., Kim, C., Collins J.F. (2012) Multiple Menkes copper ATPase (Atp7a) transcript and protein variants are induced by iron deficiency in rat duodenal enterocytes.  J. Trace Elem. Biol. Med. 26(2-3):109-14

Ranganathan, P.N., Lu, Y., Fuqua, B.K., Collins, J.F. (2012) Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes. Proc. Natl. Acad. Sci. USA. 109(9):3564-9.

Ranganathan, P.N., Lu, Y., Fuqua, B.K., Collins, J.F. (2012) Immunoreactive Hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. Biometals. 25(4):687-95.

Klevay, L., Collins, J.F. (2011) Copper. Adv. Nutr. 2(6):520-22.

Jiang, L, Ranganathan, P.N., Lu, Y., Kim, C., Collins J.F. (2011) Exploration of the Copper Related Compensatory Response in the Belgrade Rat Model of Genetic Iron Deficiency. Am. J. Physiol. Gastrointest. Liver Physiol. 301(5):G877-86.

Ranganathan, P.N., Lu, Y., Jiang, L., Kim, C. Collins, J.F. (2011) Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake. Blood. 118(11):3146-53.

Xie, L., Collins, J.F.  (2011) Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2α) in intestinal epithelial cells. Am. J. Physiol. Cell Physiol. 300(6):C1298-305.

Hu, Zihua, Gulec, S., Collins, J.F. (2010) Cross-Species Comparison of Genome-Wide Gene Expression Profiles Reveals a Preferential Induction of Hypoxia Inducible Factor (HIF) Responsive Genes in Iron Deprived Intestinal Epithelial Cells. Am. J. Physiol. Cell Physiol.299:930-938.

Textbook Chapters:

Collins, J.F. (2011) Copper. In Modern Nutrition in Health and Disease, 11th Edition; Lipcott, Williams and Wilkins.

Kiela, P.R., Collins, J.F., Ghishan, F.K. (2011) Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate and Magnesium. In Physiology of the Gastrointestinal Tract, 5th Edition. Academic Press.

Collins, J. F. and Anderson, G.J. (2011) Mechanisms of Intestinal Iron Absorption. In Physiology of the Gastrointestinal Tract, 5th Edition. Academic Press.

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