University of Florida

Clayton E. Mathews Laboratory - Department of Pathology, Immunology & Laboratory Medicine

Skip to main Content   Local Links   Search   Main Navigation   Resources   Website   Social   Address   What is this view

About Dr. Mathews

Clayton Mathews, Sebastian Family Professor for Diabetes Research

Despite continuing improvements in the ability to treat individuals with type 1 diabetes (commonly referred to as juvenile diabetes), the need to identify a true cure for the disease remains. In an attempt to meet this need, Dr. Mathews performs studies seeking to improve our collective understanding on the means by which type 1 diabetes develops, both in humans and in mouse models of the disease. His efforts are extremely novel in that while the majority of researchers addressing the notion of how the disease develops focus on identifying defects in cells of the immune system, the guiding hypothesis of Dr. Mathews research is that insulin-secreting pancreatic beta cells are active contributors to the processes that leads to type 1 diabetes. This concept was birthed through his early works, demonstrating that beta cells had unusual reductions in their self-defense mechanisms and that this reduction was important in the initiation of type 1 diabetes.His studies later demonstrated that beta cells from different strains of mice varied in their resistance to destruction by the immune system. These novel findings proved to be highly influential to the research community since prior to these efforts, evidence suggesting that beta cells could resist immune destruction did not exist. These findings also led him to postulate that genetic factors related to this feature may underlie natural resistance to type 1 diabetes; a concept for which has recently found support.Dr. Mathews’ continuing attempts to discover genes that beta cells naturally employ to ward off destructive mechanisms used by the immune system will undoubtedly have important ramifications for efforts in organ transplantation, stem cell engineering and pharmacological-based studies seeking to cure type 1 diabetes.

Related Links

Footer

UF Health - University of Florida Health

Together we discover. Together we teach.
Together we care for our patients and our communities.
Together we create unstoppable momentum.

The University of Florida

The Foundation for The Gator Nation

Resources

Utility Links

Center for Immunology and Transplantation

Social links

Address

  • UF Health is a collaboration of the University of Florida Health Science Center, Shands hospitals and other health care entities.
  • © 2017 © 2017   University of Florida Health, Gainesville, FL 32611; (352) 392-3261

What is this view?

You are using a dynamic assistive view of the University of Florida site. It has all the same data and features of the original site but formatted just with assistive users in mind. It has links and content reorganized to aid assistive users and has controls at the bottom under assistive options that allow you to control key aspects such as font size and contrast colors etc.
This is not a separate text-only site, it's a dynamic view that uses unique technology from Usablenet to give assistive users better, more accessible access to the same content and features as all users that use the graphic view of the site.