Institute for Biological Interfaces of Engineering

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  • The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures
    Mon, 25 Aug 2014 11:43:10 EST
  • Fibrillar collagen is the primary component of the cardiac interstitial extracellular matrix. This extracellular matrix undergoes dramatic changes from birth to adulthood and then into advanced age. As evidence, fibrillar collagen content was compared in sections from neonates, adult, and old hearts and was found to increase at each respective age. Cardiac fibroblasts are the principle cell type that produce and control fibrillar collagen content. To determine whether fibroblast production, proc...

  • In vitro 3D bone tissue models, from cells to controlled and dynamic environment
    Mon, 25 Aug 2014 11:43:10 EST
  • Most of our knowledge of bone cell physiology is derived from experiments carried out in vitro on polystyrene substrates. However, these traditional monolayer cell cultures do not reproduce the complex and dynamic 3-dimensional (3D) environment experienced by cells in vivo. Thus, there is a growing interest in the use of 3D culture systems as tools for understanding bone biology. These in vitro engineered systems, less complex than in vivo models, should ultimately recapitulate and control the m...

  • Application and Assessment of Optical Clearing Methods for Imaging of Tissue-Engineered Neural Stem Cell Spheres
    Mon, 25 Aug 2014 11:43:09 EST
  • Three dimensional (3D) cell culture is an important tool that facilitates biological discoveries by bridging the divide between standard two-dimensional cell culture and the complex, high cell density in vivo environment. Typically, the internal structures of 3D tissue-engineered samples are visualized through an involved process of physical sectioning, immunostaining, imaging, and computational reconstruction. However, recent progress in tissue clearing methods has improved optical imaging dept...

  • Illuminating breast cancer invasion: diverse roles for cell-cell interactions
    Mon, 25 Aug 2014 11:43:08 EST
  • Metastasis begins when tumors invade into surrounding tissues. In breast cancer, the study of cell interactions has provided fundamental insights into this complex process. Powerful intravital and 3D organoid culture systems have emerged that enable biologists to model the complexity of cell interactions during cancer invasion in real-time. Recent studies utilizing these techniques reveal distinct mechanisms through which multiple cancer cell and stromal cell subpopulations interact, including p...

  • Human melanocytes form a PAX3-expressing melanocyte cluster on Matrigel by the cell migration process
    Mon, 25 Aug 2014 11:43:08 EST
  • BACKGROUND: The interactions between human epidermal melanocytes and their cellular microenvironment are important in the regulation of human melanocyte functions or in their malignant transformation into melanoma. Although the basement membrane extracellular matrix (BM-ECM) is one of major melanocyte microenvironments, the effects of BM-ECM on the human melanocyte functions are not fully explained at a molecular level. OBJECTIVE: This study was aimed to characterize the molecular and cellular i...

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