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Chemical and Biomolecular Engineering

Scott M. Husson, Ph.D.

Dr. Scott M. Husson

Professor
Bioseparations and Advanced Separation Materials

Associate Editor, Separation Science and Technology

Email: shusson@clemson.edu
Phone: 864-656-4502
Office: 126 Earle Hall

scott husson with student
Education

Ph.D., University of California at Berkeley, 1998
B.S., Pennsylvania State University, 1993

Research Interests:  Bioseparations and Advanced Separation Materials

Professor Husson's research group uses surface engineering methods, especially surface-initiated polymerization, to create advanced materials for the recovery and purification of biological products, the treatment of impaired waters, and the capture of carbon dioxide from mixed gases.

In the field of bioseparations, his group is developing next-generation membranes for protein separations and virus clearance, and using synthetic chemistry to prepare polymer nanolayers that perform molecular recognition. The group uses a number of state-of-the-art surface analytical tools to study the polymer nanolayers and their interactions with proteins and cells, in order to understand how the physical and chemical properties of the nanolayers impact their performance, whether they are to perform a selective separation, to prevent protein fouling of a membrane surface, or to detect a molecule as the recognition element of a sensor device.

In the water treatment area, Professor Husson's group is developing fouling-resistant, self-cleaning membranes. Surface-initiated polymerization is used to modify membranes with unique, responsive polymer nanostructures. Irreversible membrane fouling is minimized by controlling the chemical and environmentally responsive conformational properties of these polymer nanostructures. Here again, state-of-the-art surface analytical tools are used to study how the physical and chemical properties of the nanostructures impacts membrane performance.

In carbon capture work, Professor Husson's group is developing polymer thin-film composite membranes and sorbents for selective CO2 separations. Focus is given to the development and characterization of unique polymer selective layers. The research includes thermodynamic property measurements, the development of fundamental structure-property relationships, as well as materials separation performance testing.

Selected Publications

Wang, J.; Sproul, R.T.; Anderson, L.S.; Husson, S.M. Development of multimodal membrane adsorbers for antibody purification using atom transfer radical polymerization. Polymer, available online: http://dx.doi.org/10.1016/j.polymer.2013.12.023.

Zhou, J.; Tran, M-M.; Haldeman, A.T.; Jin, J.; Wagener, E.H.; Husson, S.M. Perfluorocyclobutyl polymer thin-film composite membranes for CO2 separations. J. Membr. Sci., 450, 478-486 (2014).

Marroquin, M.; Vu, A.; Bruce, T.; Wickramasinghe, S.R.; Husson, S.M. Location and Quantification of Biological Foulants in a Wet Membrane Structure by Cross-sectional Confocal Laser Scanning Microscopy. J. Membr. Sci., 453, 282-291 (2014).

Zhou, J.; Jin, J.; Haldeman, A.T.; Wagener, E.H.; Husson, S.M. CO2 plasticization and physical aging of perfluorocyclobutyl polymer selective layers. J. Membr. Sci., 454, 398-406 (2014).

Zhou, J.; Jin, J.; Haldeman, A.T.; Wagener, E.H.; Husson, S.M. Formation and characterization of perfluorocyclobutyl polymer thin films. J. Appl. Polym. Sci., 129, 3226-3236 (2013).

Husson, S.M. Synthesis aspects in the design of responsive membranes. In Responsive Membranes and Materials; Bhattacharyya, D., Schafer, T.; Wickramasinghe, S.R., Daunert, S., Eds.; Wiley-Blackwell: Hoboken, NJ (2013).

Weaver, J.; Husson, S.M.; Wickramasinghe, S.R. Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance and antibody recovery. Biotechnol. Bioeng., 110, 500-510 (2013).

Weaver, J.; Husson, S.M.; Wickramasinghe, S.R. Anion exchange membrane adsorbers for flow-through polishing steps: Part I. Clearance of Minute Virus of Mice. Biotechnol. Bioeng., 110, 491-499 (2013).

Wandera, D.; Husson, S.M. Assessment of fouling-resistant membranes for additive-free treatment of high-strength wastewaters. Desalination, 309, 222-230 (2013).

Shrestha, A.; Pellegrino, J.; Husson, S.M.; Wickramasinghe, S.R. A modified porometry approach towards characterization of MF membranes. J. Membr. Sci., 421, 145-153 (2012).

Chenette, H.C.S.; Robinson, J.R.; Hobley, E.; Husson, S.M. Development of high-productivity, strong cation-exchange membranes for protein capture by graft polymerization from membranes with different pore sizes. J. Membr. Sci., 423-424, 43-52 (2012).

Wang, X.; Husson, S.M.; Qian, X.; Wickramasinghe, S.R. Inverse Colloidal Crystal Ultrafiltration Membranes. Separ. Purif. Technol. 93, 33-41 (2012).

Wandera, D.; Wickramasinghe, S.R.; Husson, S.M. Modification of ultrafiltration membranes with block copolymer nanolayers for produced water treatment: the roles of polymer chain density and polymerization time on performance. J. Membr. Sci. 403, 250-260 (2012).

Cutler, H.E.J.; Husson, S.M.; Wickramasinghe, S.R. Prefiltration to suppress protein fouling of microfiltration membranes. Separ. Purif. Technol. 89, 329-336 (2012).

Bhut, B.V.; Conrad, K.; Husson, S.M. Preparation of high-performance membrane adsorbers by surface-initiated AGET ATRP in the presence of dissolved oxygen and low catalyst concentration. J. Membr. Sci. 390-391, 43-47 (2012).

Marroquin, M. Bruce, T.; Pellegrino, J.; Wickramasinghe, S.R.; Husson, S.M. Characterization of asymmetry in microporous membranes by cross-sectional confocal laser scanning microscopy. J. Membr. Sci. 374, 504-515 (2011).

Bhut, B.V.; Weaver, J.; Carter, A.R.; Wickramasinghe, S.R. Husson, S.M. The Role of Polymer Nanolayer Architecture on the Separation Performance of Anion-Exchange Membrane Adsorbers. Part II: DNA and Virus Separations. Biotechnol. Bioeng. 108, 2654–2660 (2011).

Bhut, B.V.; Weaver, J.; Carter, A.R.; Wickramasinghe, S.R. Husson, S.M. The Role of Polymer Nanolayer Architecture on the Separation Performance of Anion-Exchange Membrane Adsorbers. Part I: Protein Separations. Biotechnol. Bioeng. 108, 2645–2653 (2011).

Wandera, D.; Wickramasinghe, S.R.; Husson, S.M. Modification and Characterization of Ultrafiltration Membranes for Treatment of Produced Water. J. Membr. Sci., 373, 178–188 (2011).

Seliman, A.; Samadi, A.; Husson, S.M.; Borai, E.; DeVol, T. Preparation of polymer-coated, scintillating ion-exchange resins for monitoring of 99TC in groundwater. Anal. Chem. 83, 4759–4766 (2011).

Wickramasinghe, S.R.; Stump, E.D.; Husson, S.M.; Pellegrino, J. Understanding Virus Filtration Membrane Performance. J. Membr. Sci., 365, 160-169 (2010).

Wang, X.; Husson, S.M.; Qian, X.; Wickramasinghe, S.R. Inverse Colloidal Crystal Microfiltration Membranes. J. Membr. Sci., 365, 302-310 (2010).

Samadi, A.; Kemmerlin, R.K.; Husson, S.M. Polymerized Ionic Liquid Sorbents for CO2 Separation. Energy Fuels, 24, 5797–5804 (2010). 

Bhut, B.V.; Christensen, K.A.; Husson, S.M. Membrane Chromatography: Protein purification from E. Coli lystate using newly designed and commercial anion-exchange stationary phases.  J. Chromatogr. A, 1217, 4946–4957 (2010).

Wandera, D.; Wickramasinghe, S.R.; Husson, S.M. Stimuli-responsive membranes. J Membr. Sci., 357, 6–35 (2010).

Tomer, N.; Mondal, S.; Wandera, D.; Wickramasinghe, S.R.; Husson, S.M. Modification of Nanofiltration Membranes by Surface-initiated Atom Transfer Radical Polymerization for Produced Water Filtration. Sep. Sci. Technol. 44, 3346–3368 (2009).

Wang, X.; Husson, S.M.; Qian, X.; Wickramasinghe, S.R. Vertical cell assembly of colloidal crystal films with controllable thickness. Mater. Lett. 63, 1981–1983 (2009).

Wickramasinghe, S.R., Bower, S.E., Chen, Z., Mukherjee, A., Husson, S.M. Relating the Pore Size Distribution of Ultrafiltration Membranes to Dextran Rejection. J. Membr. Sci. 340, 1–8 (2009).

Bhut, B.V.; Husson, S.M. Dramatic performance improvement of weak anion-exchange membranes for chromatographic bioseparations. J. Membr. Sci. 337, 215–223 (2009).

Loh, S.; Beuscher, U.; Poddar, T.K.; Porter, A.G.; Wingard, J.M.; Husson, S.M.; Wickramasinghe, S.R. Interplay Among Membrane Properties, Protein Properties and Operating Conditions on Protein Fouling During Normal Flow Microfiltration. J. Membr. Sci. 332, 93–103 (2009).

Bhut, B.V.; Wickramasinghe, S.R.; Husson, S.M. Preparation of high-capacity, weak anion-exchange membranes for protein separations using surface-initiated atom transfer radical polymerization. J. Membr. Sci. 325, 176–183 (2008).

Singh, N.; Chen, Z.; Tomer, N.; Wickramasinghe, S.R.; Soice, N.; Husson, S.M. Modification of Regenerated Cellulose Ultrafiltration Membranes by Surface-initiated Atom Transfer Radical Polymerization. J. Membr. Sci., 311, 225–234 (2008).

Singh, N.; Wang, J.; Ulbricht, M.; Wickramasinghe, S.R.; Husson, S.M. Surface-initiated Atom Transfer Radical Polymerization: A New Method for Preparation of Polymeric Membrane Adsorbers. J. Membr. Sci. 309, 64–72 (2008).

Singh, N.; Cui, X.; Boland, T.; Husson, S.M. The Role of Independently Variable Grafting Densities and Layer Thicknesses of Polymer Nanolayers on Peptide Adsorption and Cell Adhesion. Biomaterials, 28, 763–771 (2007).

Li, X.; Husson, S.M. Two-Dimensional Molecular Imprinting Approach to Produce Optical Biosensor Recognition Elements. Langmuir, 22, 9658–9663 (2006).

Singh, N.; Husson, S.M.; Zdyrko, B.; Luzinov, I. Surface Modification of Microporous PVDF Membranes by ATRP. J. Membr. Sci. 262, 81–90 (2005).

Wei, X.; Li, X. Husson, S.M. Surface Molecular Imprinting by Atom Transfer Radical Polymerization. Biomacromolecules, 6, 1113–1121 (2005).

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