University of Florida

Department of Neurology

Skip to main Content   Search   Main Navigation   Resources   Website   Social   Address   What is this view

Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation In Essential Tremor

Published: November 9th, 2017

Category: News and Events

Congratulation to Robert Eisinger et al. (Dr. Michael Okun’s lab) on the publication of “Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation In Essential Tremor,” in the November issue of Movement Disorders, Clinical Practice.



The ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) stimulation for tremor control has recently emerged and some groups believe this approach may address long-term reduction of benefit seen with VIM-DBS.


To compare clinical outcomes and DBS programming in the long-term between VIM and cZI neurostimulation in ET-DBS patients.

Materials and Methods

A retrospective review of 53 DBS leads from 47 patients was performed. Patients were classified into VIM or cZI groups according to the location of the activated DBS contact. Demographics, DBS settings, and Tremor Rating Scale scores were compared between groups at baseline and yearly follow-up to 4 years after DBS. Student t-tests and ANOVA were used to compare variables between groups.


Relative to baseline, an improvement in ON-DBS tremor scores was observed in both groups from 6 months to 4 years post-DBS (p<0.05). Although improvement was still significant at 4 years, scores from month 6 to 2 years were comparable between groups but at 3 and 4 years post-DBS the outcome was better in the VIM group (p<0.01). Stimulation settings were similar across groups, although we found a lower voltage in the VIM group at 3 years post-DBS.


More ventral DBS contacts in the cZI region do improve tremor, however, VIM-DBS provided better long-term outcomes. Randomized controlled trials comparing cZI vs VIM targets should confirm these results.


UF Health - University of Florida Health

Together we discover. Together we teach.
Together we care for our patients and our communities.
Together we create unstoppable momentum.

The University of Florida

The Foundation for The Gator Nation


Utility Links


Social links


  • UF Health is a collaboration of the University of Florida Health Science Center, Shands hospitals and other health care entities.
  • © 2017 © 2017   University of Florida Health, Gainesville, FL 32611; (352) 392-3261

What is this view?

You are using a dynamic assistive view of the University of Florida site. It has all the same data and features of the original site but formatted just with assistive users in mind. It has links and content reorganized to aid assistive users and has controls at the bottom under assistive options that allow you to control key aspects such as font size and contrast colors etc.
This is not a separate text-only site, it's a dynamic view that uses unique technology from Usablenet to give assistive users better, more accessible access to the same content and features as all users that use the graphic view of the site.