Roger Giese

Senior Faculty Fellow, Professor of Chemistry and
Biomedical Science Director of the Environmental 
Cancer Research Program 

The Barnett Institute, 341 Mugar 
Northeastern University 
360 Huntington Avenue 
Boston MA 02115 
email r.giese@neu.edu 
voice: 617-373-3227 
fax: 617-373-8720, -2855 

Dr. Giese’s research is in the detection and identification of trace analytes such as genotoxic chemicals, DNA adducts, environmental contaminants, steroids, and bio-active peptides by mass spectrometry.  The work combines analytical chemistry, organic chemistry, and biochemistry to advance the reagents and techniques available for sample reparation.  Novel tags are developed for derivatization to increase analyte response and selectivity.

Environmental Cancer Research Program Site>>

Prof. Giese's Research Group Site>>

Selected Publications

Shao, G., Kautz, R., Peng, S., Cui, G., Giese, R. W. (2007) Calibration by NMR for quantitative analysis:
p-Toluenesulfonic acid as a reference substance, J. Chromatogr. A, 1138, 305-308.

Yong. L. C., Schulte, P. A., Kao, C-K., Giese, R. W., Boeniger, M. F., Strauss, G. H.S., Petersen, M. R., Wiencke, J. K. (2007) DNA Adducts in Granulocytes of Hospital Workers Exposed to Ethylene Oxide, Am. J. Ind. Med., 50, 293-302.09.

Gao, H., Wu, B., Giese, R. Zhu, A. (2007) Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis, Cell Res. 17, 345-356.

Wang, Y., Cui, G., Zhao, M., Yang, J., Wang, C. Giese, R. W., Peng, S. (2008) Bioassay-directed purification of an acidic phospholipase A2 from Agkistrodon halys pallas venom, Toxicon 51, 1131-1139.

Wang, P., Li, G., Gao, J., Zhang, X., Giese, R. W. Intensified Neutral Loss Tags and Use thereof in Mass Spectrometry, U.S. Patent 7,556,969 July 7, 2009.
177. Wang. P, Kremsky, J. N., Giese, R. W. (2009) Positive chemical ionization (PCI)-like behavior of estradiol in matrix-assisted laser desorption/ionization, Rapid Commun. Mass Spectrom., 23, 2836-2838.

Shao, G., Kautz, R., Peng, S., Cui, G., Giese, R. W., "Calibration by NMR for quantitative analysis: p-Toluenesulfonic acid as a reference substance", J. Chromatogr. A, 1138, 305-308 (2007).

Murugaiah, V., Naim, A., Peng, S., Cui, G., Giese, R. W., "4-(4'-Methyltetrafluorophenyl)-2,3,5,6-tetrafluorobenzyl bromide: A new electrophoric derivatizing reagent", J. Chromatogr113. A, 4, 338-340 (2006).

Shimelis, O., Giese, R. W., "Nuclease P1 digestion/high-performance liquid chromatography, a practical method for DNA quantitation", J. Chromatogr. A., 1117, 132-136 (2006).

Kao, C-Y., Giese, R.W., Measurement of N7(2-Hydroxyethyl)guanine in Human DNA by Gas Chromatography Electron Capture Mass Spectrometry, Chem. Res. Toxicol, 18, 70-75 (2005).

Pashkova, A., Chen, H., Rejtar, T., Zang, X., Giese, R., Andreev, V., Moskovets, E. Karger, Barry L. "Coumarin Tags for Improved Analysis of Peptides by MALDI-TOF MS and MS/MS. II. Alexa Fluor 350 Tag for Increased Peptide and Protein Identification by LC-MALDI-TOF/TOF MS", Anal. Chem., 4(1), 129-135 (2005).

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