2ND SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS

Printer-friendly version Printer-friendly version
Details and Registration Information:  pdf   MS Word   
Held On:    Mon 12/10/12 – Thurs 12/13/12   
Lodging:    Doubletree Hotel Birmingham
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax (205) 933-0920
*mention that you are coming at the request of UAB for our short course for the rate ($114/night; gov't rate not offered)   
Location:    Meeting Room on the ground floor of the:
Doubletree Hotel Birmingham
808 South 20th Street
Birmingham, AL 35205
View more information.   

  • Overview & Agenda
  • Faculty
  • Contact

Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. In this regard, we are organizing a NHGRI funded four-day short course, calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.

Schedule of Events: [ PDF file]

**NOTE: You will need Microsoft Silverlight to view videos.

Mon 12/10/12 - UAB in Birmingham, AL
Time    Topic    Speaker    Resource(s)   
08:30 - 09:15 AM    Registration    Derry Crawford     
09:15 - 09:30 AM    Introductory Remarks    Hemant Tiwari,  PhD     
09:30 - 10:45 AM    Overview of Genetics & Genomics (Intro: Sequencing for Variation & Functional Genomics)    Greg Barsh, PhD    Video    
10:45 - 11:00 AM    BREAK   
11:00 - 12:15 PM    Technical overview of NGS (Platforms; chemistry; library construction)    Shawn Levy, PhD    Video    
12:15 - 1:30 PM    Lunch   
01:30 - 02:45 PM    Primary Data Analysis (Base calling; alignment; QC; variant calling)    Shawn Levy, PhD    Video    
02:45 - 03:00 PM    BREAK   
03:00 - 04:15 PM    Copy Number & Structural Variants (biology; experimental methods; analysis)    Devin Absher, PhD    Video    
04:15 - 04:30PM    BREAK   
04:30- 05:00 PM    Discussion (Q & A)    All Faculty     

Tue 12/11/12 - HudsonAlpha Institute for Biotechnology in Huntsville, AL
Time    Topic    Speaker    Resource(s)   
07:30 - 07:45 AM    Gather in Hotel Lobby for departure   
07:45 - 9:15 AM    Bus Transportation to HudsonAlpha in Huntsville   
09:15 - 9:30AM    Gather in HudsonAlpha meeting room   
09:30 - 10:00 AM    Computing Needs for NGS (Computing & storage needs; data handling)    Braden Boone, MS, MIT    Video    
10:00 - 11:00 AM    DNA Sequence Variant Annotation and Analysis    Greg Cooper, PhD    Video    
11:00 - 11:15 PM    BREAK   
11:15 - 12:15 PM    RNA-seq (mRNA & microRNA; EDGE RNA-seq, a SAGE-like, Counting Method Developed by Greg Barsh's lab)    Jay Gertz, PhD    Video    
12:15 - 01:30 PM    LUNCH   
01:30- 02:30 PM    Genome-scale DNA methylation analysis    Devin Absher, PhD    Video    
02:30- 03:30 PM    ChIP-seq (protein:DNA Interactions on a Genome-wide Scale)    Rick Myers, PhD    Video    
03:30 - 03:45 PM    BREAK   
03:45 - 05:00 PM    Discussion (Q & A) & Tour of sequencing facility    All Faculty     
05:00 - 06:30 PM    Bus Transportation to Hotel in Birmingham   

Wed 12/12/12 - UAB in Birmingham, AL
Time    Topic    Speaker    Resource(s)   
09:00 - 10:15 AM    Analysis of  Whole Genome Transcriptome Sequencing Data    Xiangqin Cui, PhD    Video    
10:15 - 10:30 AM    BREAK   
10:30 - 11:45AM    Analysis of NGS data using Galaxy    David Crossman, PhD    Video    
11:45 - 01:15 PM    Lunch   
01:15 - 02:30 PM    Whole Genome 3D Regulation Analysis Using Sequencing    Shili Lin, PhD    Video    
02:30 - 02:45 PM    BREAK   
03:00 - 04:15 PM    Cloud Computing and Semantic Web application to High-Dimensional Biomedical Data    Jonas Almeida, PhD    Video    
04:15 - 05:00 PM    Discussion (Q & A)    All Faculty     

Thu 12/13/12 - UAB in Birmingham, AL
Time    Topic    Speaker    Resource(s)   
09:00 - 10:15 AM    Rare Variants Association Analysis    Suzanne Leal, PhD    Video    
10:15 - 10:30 AM    BREAK   
10:30 - 11:45 AM    The 1000 Genomes Project: Behind and Beyond the Creation of Phase 1 Data    Yun Li, PhD    Video    
11:45- 01:15 PM    Lunch   
01:15 - 02:30 PM    Assembling NGS data    Degui Zhi, PhD    Video    
02:30 - 03:00 PM    Discussion (Q & A)    All Faculty     

UAB Faculty:

External Faculty:

Full List of Rotating Faculty can be found by Click here.

Contact Information:

Logistics: Wanda Skipwith or Derry Crawford
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193 or 975-9298
Email: Statgenetics@uab.edu

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420B
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

Sponsors:    National Human Genome Research Institute   
Section on Statistical Genetics, University of Alabama at Birmingham    
HudsonAlpha    

NHGRI Disclaimer: This material is based upon work supported by the National Human Genome Research Institute ( NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.

Assistive Options

Top of page


Assistive Options

Open the original version of this page.

Usablenet Assistive is a Usablenet product. Usablenet Assistive Main Page.