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Basic and Translational Research

The USA Mitchell Cancer Institute focuses on research to accelerate the translation of new knowledge into novel therapies and diagnostic tools.

Laurie Owen,
Associate Director of Basic and Translational Research

• Identification of novel gene targets and mechanisms of action in cancer pathogenesis
• Role of transcription regulatory proteins and complexes in tumor metastasis
• Identification of proteomic markers for early cancer diagnosis and their trace analysis in biological fluids and tissues
• Cancer stem cell identification and characterization
• Identification and manipulation of factors that modulate DNA damage levels and repair efficiency
• Role of growth factor receptors in cancer cell metabolism
• Discovery and validation of novel tumor biomarkers associated with cancer progression, metastasis and therapeutic responses
• Identification and characterization of non-coding RNA (microRNAs) associated with tumor progression and therapeutic responses

Click here for a photo slideshow of our research environment

Click here for a video regarding student studies in research at the Mitchell Cancer Institute

Principal Investigators at the Mitchell Cancer Institute include:

Adam Keeton, Ph.D., Research Assistant Professor of Oncologic Sciences

Laurie Owen, Ph.D., Barbara Colle Chair, Associate Director of Basic and Translational Sciences and Professor of Oncologic Sciences

Lewis Pannell, Ph.D., Professor of Oncologic Sciences and Head, Proteomics and Mass Spectrometry Laboratory

Gary Piazza, Ph.D., Chief, Drug Discovery Research Center, Abraham A. Mitchell Distinguished Investigator and Professor of Oncologic Sciences

Eddie Reed, MD, Clinical Director, Abraham Mitchell Distinguished Investigator and Professor of Oncologic Sciences

Rodney Rocconi, MD, Abraham Mitchell Clinical Cancer Research Scholar, Staff Physician, Gynecologic Oncology Sciences and Assistant Professor of Interdisciplinary Clinical Oncology, Deputy Associate Director for Clinical Research

Lalita Shevde-Samant, Ph.D., Associate Professor of Oncologic Sciences

Rajeev Samant, Ph.D., Associate Professor of Oncologic Sciences

Ajay Singh, Ph.D., Assistant Professor of Oncologic Sciences

Seema Singh, Ph.D., Instructor of Oncologic Sciences

Ming Tan, MD, Ph.D., Vincent F. Kilborn, Jr., Cancer Research Scholar and Associate Professor of Oncologic Sciences

Yaguang Xi, M.D., Ph.D., Assistant Professor of Oncologic Sciences

Bing Zhu, Ph.D., Research Assistant Professor of Oncologic Sciences

Member Investigators:

Mikhail Alexeyev, Ph.D.
Mitochondrial DNA damage, repair, and degradation. Effect of mtDNA alterations on properties of cancer cells.

Oystein Fodstad, M.D., Ph.D.
Cancer biology of metastatic disease, detection and clinical importance of micrometastatic disease
http://www.southalabama.edu/mci/fodstad.html

Richard Honkanen, Ph.D.
Serine/threonine protein phosphatases in cancer
http://www.southalabama.edu/clb/faculty/honkanen.htm

Susan LeDoux, Ph.D.
Role of environmental agents in the etiology of cancer; cellular responses to DNA damage; mechanisms of DNA damage and repair
http://www.southalabama.edu/com/cellbiology/ledoux.html

Wensheng Lin, Ph.D.
ER-stress response signalling; interferon-gamma induced medulloblstoma in the developing cerebellum
http://www.southalabama.edu/com/cellbiology/lin.html

Glenn Wilson, Ph.D.
DNA damage and repair in the initiation and promotion of cancer and the role of these processes in the toxic actions of chemotherapeutic agents
http://www.southalabama.edu/com/cellbiology/wilson.html

For more information about research at the USAMCI contact:

Dr. Laurie Owen,
Barbara Colle Chair and Associate Director,
Basic and Translational Sciences
USA Mitchell Cancer Institute,
1660 Springhill Avenue
Mobile, Alabama 36604

Phone: (251) 445-9807
Fax: (251) 460-6994
lowen@usouthal.edu

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