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Bing Zhu, Ph.D.

Research Assistant Professor of Oncologic Sciences

Office:
USA Mitchell Cancer Institute
1660 Springhill Avenue
Mobile, AL. 36604
(251) 445-8416
(251) 460-6994 fax
bzhu@usouthal.edu

Research Interests:
-Cancer chemoprevention and anti-cancer drug development
-Phosphodiesterases and cAMP/cGMP signaling in cancer biology
-Intracellular signaling compartmentalization in anti-cancer therapy
-Angiogenesis between cancer and normal tissues in lung cancer chemotherapy

Honors, Professional Organizations, and Achievements:
-Member, American Association for Cancer Research, 2002-2007
-Member, The American Physiological Society, 2005-present
-Ad hoc Reviewer, Medical Science Monitor, 2006-present

Education:
-Postdoctoral Fellow, University of South Alabama College of Medicine, 1997-2002
-Ph.D., Pharmacology, Peking Union Medical College and Chinese Academy of Medical Science, 1991-1996
-B.S., Pharmacy, Beijing Medical University, 1987-1991

Professional Appointments:
-Assistant Professor, Beijing Medical University, National Key Laboratory, P. R. China, 1996-1997
-Research Associate, Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama, 2002-2005
-Instructor, Department of Pharmacology, University of South Alabama College of Medicine, 2005-2008
-Assistant Professor, Center for Lung Biology, Department of Pharmacology, University of South Alabama College of Medicine, 2008-2011
-Assistant Professor of Oncologic Sciences, Drug Discovery, Mitchell Cancer Institute, University of South Alabama, 2011-present

The novel targets of intracellular signaling of cyclic nucleotides and phosphodiesterases in cancer therapy, chemoprevention, and new drug development.

1. Feinstein, W., Zhu, B., Leavesley, S.J., Sayner, S.L., Thomas, C.R. (2011) Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells. Am J Physiol Cell Physiol. In press.

2. Zhu, B., Zhang, L., Creighton, J., Alexeyev, M., Strada, S.J., Stevens, T. (2010) Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier. Am J Physiol Lung Cell Mol Physiol. 299: L493-L501.

3. Zhu, B., Zhang, L., Alexeyev, M., Alvarez, D., Strada, S.J., Stevens, T. (2009) Type 5 phosphodiesterase is a critical determinant of the lung endothelial cell angiogenic phenotype. Am J Physiol Lung Cell Mol Physiol. 296: L220-L228.

4. Ji, D.B., Zhu, M.C., Zhu, B., Zhu, Y.Z., Li, C.L., Zhu, H.B. (2008) Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1a-VEGF pathway and regulation of Bcl-2/Bax. J Cardiovasc Pharmacol. 52: 191–202.

5. Schmidt, E.P., Damarla, M., Rentsendorj, O., Servinsky, L.E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P.M., Pearse, D.B. (2008) Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 295: L1056-L1065.

6. Creighton, J., Zhu, B., Alexeyev, M., Stevens, T. (2008) Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121: 110-119.

7. Zhu, B., Strada, S.J. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma and pulmonary/cardiovascular vessels (Review). (2007) Curr Top Med Chem. 7: 437-454.

8. Zhu, B., Liu, G.T., Wu, R.S., Strada, S.J. (2006) Chemoprevention of Bicyclol against hepatic preneoplastic lesions. Cancer Biol Ther. 5: 1665-1673.

9. Zhu, B., Liu, G.T., Zhao, Y.M., Wu, R.S., Strada, S.J. (2006) Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated P-glycoprotein, GST-P and Bcl-2. Cancer Biol Ther. 5: 536-543.

10. Zhu, B., Zhang, L.H., Zhao, Y.M., Cui, J.R., Strada, S.J.(2006) 8-Chloroadenosine induced HL-60 cell growth inhibition, differentiation and G1 arrest involves attenuated cyclin D1 and telomerase but up-regulated p21WAF1/CIP1. J Cell Biochem. 97: 166-177.

11. Zhu, B., Strada, S.J., Stevens, T. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates cell growth and apoptosis of pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 289: L196-L206.

12. Zhu, B., Vemavarapu, L., Thompson, W.J., Strada, S.J. (2005) Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cell. J Cell Biochem. 94: 336-350.

13. Zhu, B., Kelly, J.J., Vemavarapu, L., Strada, S.J., Thompson, W.J. (2004) Activation and induction of cyclic AMP phosphodiesterase (PDE 4) in rat pulmonary microvascular endothelial cells. Biochem Pharmacol. 68: 479-491.

14. Thompson, W.J., Ashikaga, T., Kelly, J.J., Liu, L., Zhu, B., Vemavarapu, L., Strada, S.J. (2002) Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4). Biochem Pharmacol. 63: 797-807.

15. Thompson, W.J., Piazza, G.A., Li, H., Liu, L., Fetter, J., Zhu, B., Sperl, G., Ahnen, D., Pamukcu, R. (2000) Exisulind induction of apoptosis involves guanosine 3’,5’-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated ß -catenin. Cancer Res 60: 3338-3342.

-1 R01 HL094455-01A1
Period: 09/01/09-08/31/11
Provider: NIH
Title: cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
Role: Co-Investigator (PI: RICH, T)

-0865356E Beginning Grant-in-Aid
Period: 07/01/08-06/30/10
Provider: American Heart Association, Southeast
Title: PDE5 and Endothelial Cell Angiogenesis
Role: Principal Investigator

-0665169 Beginning Grant-in-Aid
Period: 07/01/06-06/30/08
Provider: American Heart Association, Southeast
Title: Cyclic GMP phosphodiesterase 5 in control of apoptosis and growth inhibition in lung endothelium
Role: Principal Investigator

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