Andreas H. Kottmann, PhD

Associate Medical Professor
Physiology and Pharmacology

Education

M.S. (Molecular Biology and Organic Chemistry) University of Cologne, Germany, 1984
Research Bursar (Molecular Endocrinology), Imperial Cancer Research Fund, London, UK, 1985
Ph.D. (Molecular Immunology) Max Planck Institute for Immunobiology and Albert Ludwig University Freiburg, Germany, 1991

Research Interests

Dr. Kottmann’s research aims to understand the regulation of competitive processes that on one side lead to the structural and functional stability of the central nervous system throughout life while allowing at the same time structural and functional plasticity necessary for learning and memory. We focus our efforts on the reciprocal interactions of the ascending dopaminergic system of the mesencephalon and the cholinergic system of the basal forebrain, and the spinal motor neuron system. Our basic research is of relevance to two prominent, progressive neurodegenerative disorders, Parkinson’s Disease and Amyotrophic Lateral Sclerosis (ALS).

•  Neurogenesis in the adult CNS
•  Basal Ganglia Function
•  Muscle Plasticity and Repair
•  Parkinson’s Disease and Basal Ganglia Disorders
•  Modeling Progressive Neurodegenerative Diseases by Recombinant DNA Technologies in Mice
•  Visualization and Manipulation of Basal Ganglia and Spinal Motor Circuits by Genetic Gene Expression Tracing and Viral Transduction Techniques.
•  Personalized Medicine Approaches in Psychiatry, Neurology and Oncology

Publications

Articles (Peer Reviewed):

Zou Y-R., A.H. Kottmann, M. Koruda, I. Taniuchi and D.R. Littman (1998) “Function of the Chemokine Receptor CXCR4 in Haematopoiesis and in Cerebellar Development” Nature 393: 595-598

Kalachikov S., O Evgrafov, B Ross, M Winawer, C Barker-Cummings, F P Boneschi, C.Choi, P Morozov, K Das, E Teplitskaya, A Yu, E Cayanis, G Penchaszadeh, A.H. Kottmann, T A. Pedley, W. A. Hauser, R Ottman and T. C. Gilliam (2002) “Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features”. Nature Genetics 30: 335 – 341

Brown LE., A.H. Kottmann, and S.Brown (2003) “Immunolocalization of Zic2 expression in the developing mouse forebrain.” Gene Expr. Patterns 3: 361-7.

Lewis PM., A. Litli-Grinde, R. Smeyne, A.H. Kottmann and A.P. McMahon (2004) “Sonic Hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum”. Development, 270: 393-410.

Jeong J., J. Mao, T. Tenzen, A.H. Kottmann and A.P. McMahon (2004) “Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordial” Genes and Development 18: 937 – 951.

Leonardo E.D.; J. W. Richardson-Jones; E. Sibille; A. H. Kottmann; R. Hen, (2005) “Molecular Heterogeneity along the Dorsal-Ventral Axis of the Murine Hippocampal CA1 field: A microarray analysis of gene expression”. J. Neuroscience 137: 177-186

Yun SW, Platholi J, Flaherty MS, Fu W, Kottmann AH, Toth M (2006) “Fmrp is required for the establishment of the startle response during the critical period of auditory development”. Brain Research. Brain Research. 1110: 159-165.

Schwegmann A, Guler R, Cutler AJ, Arendse B, Horsnell WG, Flemming A, Kottmann AH, Ryan G, Hide W, Leitges M, Seoighe C, Brombacher F. (2007) “Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes”. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16251-6. Epub 2007 Oct 3

Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL. (2009) “Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning”. Gastroenterology. 2009 Aug;137(2):618-28.

Last Updated: 1/7/13